For R&D use only.

(3-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol

  • Catalog NO.:A941216
  • CAS No. : 1788873-94-8
  • Molecular Formula:C15H31NO2Si
  • Molecular Weight: 285.50
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Product Details

CAS Number 1788873-94-8 Appearance
Catalog Number A941216 MDL Number
Molecular Formula C15H31NO2Si Molecular Weight 285.50
Boiling Point Melting Point
Flash Point Density
Synonyms (3-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H315-H319 Class
Precautionary Statements P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 Packing Group

Description

Ribociclib Free Base, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.

1211441-98-3 (free base)

1211443-80-9 (HCl)

1374639-75-4 (succinate)

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(3-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol
(3-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol