For R&D use only.


  • Catalog NO.:A851963
  • CAS No. : 57103-03-4
  • Molecular Formula:C14H7N3
  • Molecular Weight: 217.23
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Product Details

CAS Number 57103-03-4 Appearance Off-white powder
Catalog Number A851963 MDL Number MFCD24549598
Molecular Formula C14H7N3 Molecular Weight 217.23
Boiling Point 516.4±30.0°Cat760mmHg Melting Point
Flash Point Density
Synonyms 9H-Carbazole-3,6-dicarbonitrile
Storage Condition Store in a tightly closed container,in a cool and dry place


GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H302-H315-H319-H335 Class
Precautionary Statements P261-P305+P351+P338 Packing Group


Talazoparib, also known as BMN-673 and MDV-3800, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity (PARP1 IC50 = 0.57 nmol/L). Talazoparib acts as an inhibitor of poly ADP ribose polymerase(PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage. Talazoparib is theorized to have a higher potency than olaparib due to the additional mechanism of action called PARP trapping. PARP trapping is the mechanism of action where the PARP molecule is trapped on the DNA, which interferes with the cells ability to replicate. Talazoparib is found to be ~100 fold more efficient in PARP trapping than olaparib.

1373431-65-2 (tosylate)

1207456-01-6 (free base)

1207454-56-5 (racemic)

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