For R&D use only.

N1,N1-Diethylbenzene-1,4-diamine sulfate

  • Catalog NO.:A941157
  • CAS No. : 6283-63-2
  • Molecular Formula:C10H18N2O4S
  • Molecular Weight: 262.33
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Product Details

CAS Number 6283-63-2 Appearance
Catalog Number A941157 MDL Number MFCD00012993
Molecular Formula C10H18N2O4S Molecular Weight 262.33
Boiling Point 471.8°C at 760 mmHg Melting Point
Flash Point Density
Synonyms N1,N1-Diethylbenzene-1,4-diamine sulfate
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H302 Class
Precautionary Statements P280-P305+P351+P338 Packing Group

Description

Rosiptor, also known as AQX-​1125 is a potent and selective SHIP1 activator currently in clinical development. AQX-1125 inhibited Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduced cytokine production in splenocytes, inhibited the activation of mast cells and inhibited human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy. As shown in the mouse model of LPS-induced lung inflammation, the efficacy of the compound is dependent on the presence of SHIP1. Pharmacological SHIP1 activation may have clinical potential for the treatment of pulmonary inflammatory diseases.

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N1,N1-Diethylbenzene-1,4-diamine sulfate
N1,N1-Diethylbenzene-1,4-diamine sulfate