N1,N1-Diethylbenzene-1,4-diamine sulfate

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For R&D use only.

Catalog NO.：A941157
CAS No. : 6283-63-2
Molecular Formula：C₁₀H₁₈N₂O₄S
Molecular Weight： 262.33

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Product Details

CAS Number	6283-63-2	Appearance
Catalog Number	A941157	MDL Number	MFCD00012993
Molecular Formula	C₁₀H₁₈N₂O₄S	Molecular Weight	262.33
Boiling Point	471.8°C at 760 mmHg	Melting Point	183-193°C
Flash Point		Density
Synonyms	N1,N1-Diethylbenzene-1,4-diamine sulfate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number	Not hazmat
Hazard Statements	H302	Class
Precautionary Statements	P280-P305+P351+P338	Packing Group

Description

Rosiptor, also known as AQX-1125 is a potent and selective SHIP1 activator currently in clinical development. AQX-1125 inhibited Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduced cytokine production in splenocytes, inhibited the activation of mast cells and inhibited human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy. As shown in the mouse model of LPS-induced lung inflammation, the efficacy of the compound is dependent on the presence of SHIP1. Pharmacological SHIP1 activation may have clinical potential for the treatment of pulmonary inflammatory diseases.

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