For R&D use only.

((2R,3S,5R)-3-acetoxy-5-(2-oxo-5-(phenylethynyl)-4-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate

  • Catalog NO.:A942196
  • CAS No. : 2607828-76-0
  • Molecular Formula:C21H20N2O6S
  • Molecular Weight: 428.46
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Product Details

CAS Number 2607828-76-0 Appearance
Catalog Number A942196 MDL Number
Molecular Formula C21H20N2O6S Molecular Weight 428.46
Boiling Point Melting Point
Flash Point Density
Synonyms ((2R,3S,5R)-3-acetoxy-5-(2-oxo-5-(phenylethynyl)-4-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate
Storage Condition Store in a tightly closed container,in a cool and dry place


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LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2. LDN-212854 exhibits some selectivity for ALK2 in preference to other BMP type I receptors, ALK1 and ALK3, which may permit the interrogation of ALK2-mediated signaling, transcriptional activity, and function. LDN-212854 potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. The bone morphogenetic protein (BMP) signaling pathway has essential functions in development, homeostasis, and the normal and pathophysiologic remodeling of tissues. Small molecule inhibitors of the BMP receptor kinase family have been useful for probing physiologic functions of BMP signaling in vitro and in vivo and may have roles in the treatment of BMP-mediated diseases.

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((2R,3S,5R)-3-acetoxy-5-(2-oxo-5-(phenylethynyl)-4-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate
((2R,3S,5R)-3-acetoxy-5-(2-oxo-5-(phenylethynyl)-4-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate