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  • Catalog NO.:A947388
  • CAS No. : 86445-22-9
  • Molecular Formula:C20H19NO3
  • Molecular Weight: 321.37
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Product Details

CAS Number 86445-22-9 Appearance Off-white powder
Catalog Number A947388 MDL Number MFCD31657391
Molecular Formula C20H19NO3 Molecular Weight 321.37
Boiling Point Melting Point
Flash Point Density
Synonyms 4-(2,4-Dimethylphenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid
Storage Condition Store in a tightly closed container,in a cool and dry place


GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H302;H315;H319;H335 Class
Precautionary Statements P261;P305+P351+P338 Packing Group


Ivacaftor, also known as VX-770, is a drug used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, who account for 4–5% cases of cystic fibrosis, and is included in a combination drug, lumacaftor/ivacaftor, which is used to treat people with cystic fibrosis who have the F508del mutation in CFTR. Ivacaftor is a "potentiator" of CFTR, meaning it increases the probability that the defective channel will be open and allow chloride ions pass through the channel pore.

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4-(2,4-Dimethylphenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid