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  • Catalog NO.:A950819
  • CAS No. : 313397-13-6
  • Molecular Formula:C26H27N5O2
  • Molecular Weight: 441.52
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Product Details

CAS Number 313397-13-6 Appearance
Catalog Number A950819 MDL Number
Molecular Formula C26H27N5O2 Molecular Weight 441.52
Boiling Point Melting Point
Flash Point Density
Synonyms N-(3-Morpholinopropyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Storage Condition Store in a tightly closed container,in a cool and dry place


GHS Pictogram
Signal Word UN Number
Hazard Statements Class
Precautionary Statements Packing Group


Entinostat, also known as MS-275 or SNDX-275, is a potent HDAC inhibitor with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis.

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