KB-0742 dihydrochloride

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Catalogo NO.：A950618
Numero CAS : 2416874-75-2
Formula molecolare：C₁₆H₂₇Cl₂N₅
Peso molecolare： 360.33

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Dettagli del prodotto

Numero CAS	2416874-75-2	Aspetto	Yellow powder
Numero di catalogo	A950618	Numero MDL
Formula molecolare	C₁₆H₂₇Cl₂N₅	Peso molecolare	360.33
Punto di ebollizione		Punto di fusione
Punto d'infiammabilità		Densità
Sinonimi	(1S,3S)-N1-(5-(Pentan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine dihydrochloride
Condizioni di conservazione	Store in a tightly closed container,in a cool and dry place

Sicurezza

Pittogramma GHS
AVVERTENZA	Warning	Numero ONU
Dichiarazioni di pericolo	H302;H315;H319;H335	Classe
Consigli di prudenza	P261;P305+P351+P338	Gruppo di imballaggio

Descrizione

A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. IC50 value: 8 nM Target: Nav1.8 sodium channel A 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

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Le mie tracce: ARQ-531 Sodium (3R,4S,5R,6R)-2,3,4,5,6,7-hexahydroxyheptanoate dihydrate 2,6-Diaminopurine arabinoside N-(2-Chloro-6-fluorobenzyl)-5-(1H-indazol-3-yl)thiophene-3-carboxamide

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P201	Obtain special instructions before use.
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P220	Keep/Store away from clothing/…/combustible materials.
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P233	Keep container tightly closed.
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P231 + P232	Handle under inert gas. Protect from moisture.
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P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
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P322	Specific measures (see …on this label).
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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
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P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire: Use … for extinction.
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P401	Store …
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P402 + P404	Store in a dry place. Store in a closed container.
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P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Store at temperatures not exceeding … oC/…oF. Keep cool.

P501	Dispose of contents/container to..…
P502	Refer to manufacturer/supplier for information on recovery/recycling

H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
H204	Explosives (Div 1.4)
H205	Explosives （Div 1.5)
H220	Flammable gases (Category 1)
H221	Flammable gases (Category 2)
H222	Flammable aerosols (Category 1)
H223	Flammable aerosols (Category 2)
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H260	Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases (Category 1)
H261	Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases (Category 2)
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H271	Oxidising liquids;Oxidising solids (Category 1)
H272	Oxidising liquids;Oxidising solids (Category 2)
H280	Gases under pressure Compressed gas Liquefied gas Dissolved gas
H281	Gases under pressure Refrigerated liquefied gas
H290	Corrosive to Metals (Category 1)

H300	Acute toxicity,oral (Category 1, 2)
H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
H303	Acute toxicity,oral (Category 5)
H304	Aspiration hazard (Category 1)
H305	Aspiration hazard (Category 2)
H310	Acute toxicity,dermal (Category 1, 2)
H311	Acute toxicity,dermal (Category 3)
H312	Acute toxicity,dermal (Category 4)
H313	Acute toxicity,dermal (Category 5)
H314	Skin corrosion/irritation (Category 1A, B, C)
H315	Skin corrosion/irritation (Category 2)
H316	Skin corrosion/irritation (Category 3)
H317	Sensitisation, Skin (Category 1)
H318	Serious eye damage/eye irritation (Category 1)
H319	Serious eye damage/eye irritation (Category 2A)
H320	Serious eye damage/eye irritation (Category 2B)
H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
H336	Specific target organ toxicity,single exposure; Narcoticeffects (Category 3)
H340	Germ cell mutagenicity (Category 1A, 1B)
H341	Germ cell mutagenicity (Category 2)
H350	Carcinogenicity (Category 1A, 1B)
H351	Carcinogenicity (Category 2)
H360	Reproductive toxicity (Category 1A, 1B)
H361	Reproductive toxicity (Category 2)
H362	Reproductive toxicity, effects on or via lactation (Additional category)
H370	Specific target organ toxicity, single exposure (Category 1)
H371	Specific target organ toxicity, single exposure (Category 2)
H372	Specific target organ toxicity, repeated exposure (Category 1)
H373	Specific target organ toxicity, repeated exposure (Category 2)

H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
H402	Hazardous to the aquatic environment, acute hazard (Category 3)
H410	Hazardous to the aquatic environment, long-term hazard(Category 1)
H411	Hazardous to the aquatic environment, long-term hazard (Category 2)
H412	Hazardous to the aquatic environment, long-term hazard (Category 3)
H413	Hazardous to the aquatic environment, long-term hazard (Category 4)
H420	Hazardous to the ozone layer (Category 1)