HA-15
- Katalog-Nr.:A950425
- CAS-Nr. : 1609402-14-3
- Molekularformel:C23H22N4O3S2
- Molekulargewicht: 466.58
Hinweis*
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Massenanfrage
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Produktdetails
CAS-Nummer | 1609402-14-3 | Aussehen | Off-white powder |
Katalognummer | A950425 | MDL-Nummer | MFCD30377202 |
Molekularformel | C23H22N4O3S2 | Molekulargewicht | 466.58 |
Siedepunkt | Schmelzpunkt | ||
Flammpunkt | Dichte | ||
Synonyme | N-(4-(3-((5-(Dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide | ||
Lagerungszustand | Store in a tightly closed container,in a cool and dry place |
Sicherheit
GHS-Piktogramm | |||
Signalwort | Warning | UN-Nummer | |
Gefahrenhinweise | H302;H315;H319;H335 | Klasse | |
Sicherheitshinweise | P261;P305+P351+P338 | Verpackungsgruppe |
Beschreibung
Entinostat, also known as MS-275 or SNDX-275, is a potent HDAC inhibitor with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. |