5-Bromo-1H-pyrazolo[3,4-b]pyridin-3-amine
- Catalog NO.:A23544
- CAS No. : 405224-24-0
- Molecular Formula:C6H5BrN4
- Molecular Weight: 213.03
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Product Details
CAS Number | 405224-24-0 | Appearance | |
Catalog Number | A23544 | MDL Number | MFCD08059261 |
Molecular Formula | C6H5BrN4 | Molecular Weight | 213.03 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 5-bromo-1H-pyrazolo[3,4-b]pyridin-3-amine | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302 | Class | |
Precautionary Statements | P264;P270;P301+P312;P330;P501 | Packing Group |
Description
Talabostat, also known as PT-100, is dipeptidyl peptidase inhibitor with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell- dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines. |