7-Methoxy-1H-indole
- Catalog NO.:A875773
- CAS No. : 3189-22-8
- Molecular Formula:C9H9NO
- Molecular Weight: 147.18
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Product Details
CAS Number | 3189-22-8 | Appearance | |
Catalog Number | A875773 | MDL Number | MFCD00047203 |
Molecular Formula | C9H9NO | Molecular Weight | 147.18 |
Boiling Point | 297.8°C at 760 mmHg | Melting Point | |
Flash Point | Density | 1.126 | |
Synonyms | 7-Methoxy-1H-indole | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Rosiptor, also known as AQX-1125 is a potent and selective SHIP1 activator currently in clinical development. AQX-1125 inhibited Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduced cytokine production in splenocytes, inhibited the activation of mast cells and inhibited human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy. As shown in the mouse model of LPS-induced lung inflammation, the efficacy of the compound is dependent on the presence of SHIP1. Pharmacological SHIP1 activation may have clinical potential for the treatment of pulmonary inflammatory diseases. |