(4-(Chloromethyl)phenyl)(phenyl)sulfane
- Catalog NO.:A804609
- CAS No. : 1208-87-3
- Molecular Formula:C13H11ClS
- Molecular Weight: 234.74
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Product Details
CAS Number | 1208-87-3 | Appearance | Brown liquid |
Catalog Number | A804609 | MDL Number | MFCD09907764 |
Molecular Formula | C13H11ClS | Molecular Weight | 234.74 |
Boiling Point | 372°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | (4-(Chloromethyl)phenyl)(phenyl)sulfane | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
GSK2636771 is an orally bioavailable, substituted benzimidazole inhibitor of the class I phosphoinositide 3-kinase (PI3K) beta isoform with potential antineoplastic activity. PI3K beta inhibitor GSK2636771 selectively inhibits PI3K beta kinase activity in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K beta-expressing and/or PTEN-driven tumor cells. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PI3K beta is the p110-beta catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells. |