GW788388
- Catalog NO.:A872408
- CAS No. : 452342-67-5
- Molecular Formula:C25H23N5O2
- Molecular Weight: 425.48
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 452342-67-5 | Appearance | Off-white powder |
Catalog Number | A872408 | MDL Number | MFCD16038936 |
Molecular Formula | C25H23N5O2 | Molecular Weight | 425.48 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H320-H335 | Class | |
Precautionary Statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | Packing Group |
Description
GW788388 is a new TGF-beta type I receptor inhibitor with a much improved pharmacokinetic profile compared with SB431542. We studied its effect in vitro and found that it inhibited both the TGF-beta type I and type II receptor kinase activities, but not that of the related bone morphogenic protein type II receptor. Further, it blocked TGF-beta-induced Smad activation and target gene expression, while decreasing epithelial-mesenchymal transitions and fibrogenesis. |