17-DMAG HCl
- Catalog NO.:A903940
- CAS No. : 467214-21-7
- Molecular Formula:C32H49ClN4O8
- Molecular Weight: 653.21
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 467214-21-7 | Appearance | |
Catalog Number | A903940 | MDL Number | MFCD09026908 |
Molecular Formula | C32H49ClN4O8 | Molecular Weight | 653.21 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | Alvespimycin HCl;(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(2-(dimethylamino)ethoxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate hydrochloride;Alvespimycin hydrochloride | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | Class | ||
Precautionary Statements | Packing Group |
Description
Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals.1 Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer.2,3,4,5,6 This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway.7,8 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes |