Desfesoterodine
- Catalog NO.:A879440
- CAS No. : 207679-81-0
- Molecular Formula:C22H31NO2
- Molecular Weight: 341.49
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Product Details
CAS Number | 207679-81-0 | Appearance | |
Catalog Number | A879440 | MDL Number | MFCD09264524 |
Molecular Formula | C22H31NO2 | Molecular Weight | 341.49 |
Boiling Point | 490.721°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | Class | ||
Precautionary Statements | Packing Group |
Description
Desfesoterodine, also known as PNU-200577, is a major pharmacologically active metabolite of tolterodine, a new muscarinic receptor antagonist intended for the treatment of an overactive bladder. In vitro, PNU-200577 produced a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips (KB = 0.84 nM; pA2 = 9.14). In vivo, PNU-200577 was significantly more potent at inhibiting acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50 15 and 40 nmol.kg-1, respectively; P < 0.01). |