Chk2 Inhibitor II
- Catalog NO.:A871212
- CAS No. : 516480-79-8
- Molecular Formula:C20H14ClN3O2
- Molecular Weight: 363.80
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Quality Control&SDS
SDS
Product Details
CAS Number | 516480-79-8 | Appearance | Pale yellow solid |
Catalog Number | A871212 | MDL Number | MFCD08276917 |
Molecular Formula | C20H14ClN3O2 | Molecular Weight | 363.80 |
Boiling Point | 637.097°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | ML277;2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide;BML-277 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
ML-277, also known as Chk2 Inhibitor II, is a Chk2 (checkpoint kinase 2) inhibitor. BML-277 protects T cells from apoptosis by controlling the response of p53 to radiation-induced DNA breaks. ML-277 has IC50 = 15 nM; Ki = 37 nM. ML-277 shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). |