Ruxolitinib (INCB018424)
- Catalog NO.:A23578
- CAS No. : 941678-49-5
- Molecular Formula:C17H18N6
- Molecular Weight: 306.37
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Product Details
CAS Number | 941678-49-5 | Appearance | Off-white powder |
Catalog Number | A23578 | MDL Number | MFCD12031592 |
Molecular Formula | C17H18N6 | Molecular Weight | 306.37 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (3R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile;Ruxolitinib | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Ruxolitinib, also known as INC424 and INCB18424 or INCB018424, is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies. |