IPI 145
- Catalog NO.:A855658
- CAS No. : 1201438-56-3
- Molecular Formula:C22H17ClN6O
- Molecular Weight: 416.86
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Product Details
CAS Number | 1201438-56-3 | Appearance | White powder |
Catalog Number | A855658 | MDL Number | MFCD15144635 |
Molecular Formula | C22H17ClN6O | Molecular Weight | 416.86 |
Boiling Point | 757.8±60.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | Duvelisib;INK 1197;(S)-3-(1-((9H-purin-6-yl)amino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one;Duvelisib | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. |