Ribociclib(LEE011)
- Catalog NO.:A858033
- CAS No. : 1211441-98-3
- Molecular Formula:C23H30N8O
- Molecular Weight: 434.54
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Product Details
CAS Number | 1211441-98-3 | Appearance | Light yellow powder |
Catalog Number | A858033 | MDL Number | MFCD27976795 |
Molecular Formula | C23H30N8O | Molecular Weight | 434.54 |
Boiling Point | 730.8±70.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
Ribociclib Free Base, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. |