AR-11324
- Catalog NO.:A901109
- CAS No. : 1254032-66-0
- Molecular Formula:C28H27N3O3
- Molecular Weight: 453.54
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Product Details
CAS Number | 1254032-66-0 | Appearance | |
Catalog Number | A901109 | MDL Number | MFCD28502136 |
Molecular Formula | C28H27N3O3 | Molecular Weight | 453.54 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | Class | ||
Precautionary Statements | Packing Group |
Description
Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect. |