RI-1
- Catalog NO.:A851485
- CAS No. : 415713-60-9
- Molecular Formula:C14H11Cl3N2O3
- Molecular Weight: 361.61
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Product Details
CAS Number | 415713-60-9 | Appearance | Yellow powder |
Catalog Number | A851485 | MDL Number | MFCD00814248 |
Molecular Formula | C14H11Cl3N2O3 | Molecular Weight | 361.61 |
Boiling Point | 483.0±45.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA. RI-1 holds promise as an oncologic drug. Furthermore, RI-1 represents a unique tool to dissect the network of reaction pathways that contribute to DNA repair in cells. |