Bafetinib
- Catalog NO.:A861462
- CAS No. : 887650-05-7
- Molecular Formula:C30H31F3N8O
- Molecular Weight: 576.62
Note*
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Bulk Inquiry
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2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 887650-05-7 | Appearance | |
Catalog Number | A861462 | MDL Number | MFCD11973647 |
Molecular Formula | C30H31F3N8O | Molecular Weight | 576.62 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | INNO 406; NS187;N-[3-([5,5'-Bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3-(dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzamide;Lyn-IN-1 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
Bafetinib, also known as INNO-406 and NS187, is an orally bioavailable 2-phenylaminopyrimidine derivative with potential antineoplastic activity. Bafetinib specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). This agent also inhibits the Src-family member Lyn tyrosine kinase, upregulated in imatinib-resistant CML cells and in a variety of solid cancer cell types. |