KPT-185
- Catalog NO.:A888135
- CAS No. : 1333151-73-7
- Molecular Formula:C16H16F3N3O3
- Molecular Weight: 355.31
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 1333151-73-7 | Appearance | |
Catalog Number | A888135 | MDL Number | MFCD25976761 |
Molecular Formula | C16H16F3N3O3 | Molecular Weight | 355.31 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | Propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
KPT-185 is a selective and irreversible inhibitor of chromosome maintenance protein 1 (CRM1). It displays potent antiproliferative properties at submicromolar concentrations (IC₅₀ = 100-500 nM), induces apoptosis (average 5-fold increase), cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts. |