MPI-0479605
- Catalog NO.:A890404
- CAS No. : 1246529-32-7
- Molecular Formula:C22H29N7O
- Molecular Weight: 407.51
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Product Details
CAS Number | 1246529-32-7 | Appearance | Crystalline solid |
Catalog Number | A890404 | MDL Number | MFCD28099811 |
Molecular Formula | C22H29N7O | Molecular Weight | 407.51 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1. Cells treated with MPI-0479605 undergo aberrant mitosis, resulting in aneuploidy and formation of micronuclei. In cells with wild-type p53, this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway. In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis. Subsequently, cells undergo mitotic catastrophe and/or an apoptotic response. In xenograft models, MPI-0479605 inhibits tumor growth, suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics. |