Pyridone 6
- Catalog NO.:A19404
- CAS No. : 457081-03-7
- Molecular Formula:C18H16FN3O
- Molecular Weight: 309.34
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 457081-03-7 | Appearance | Off-white solid |
Catalog Number | A19404 | MDL Number | MFCD06411425 |
Molecular Formula | C18H16FN3O | Molecular Weight | 309.34 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 2-(tert-butyl)-9-fluoro-3H-benzo[h]iMidazo[4,5-f]isoquinolin-7(6H)-one;Pyridone 6 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Pyridone 6, also known CMP 6 or JAK Inhibitor I, is a pan-Janus-activated kinase inhibitor, Pyridone 6 interferes with JAK kinase activity by interacting within the ATP-binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively. Pyridone 6 suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression. Pyridone 6 induces growth inhibition of multiple myeloma cells |