Plinabulin
- Catalog NO.:A852456
- CAS No. : 714272-27-2
- Molecular Formula:C19H20N4O2
- Molecular Weight: 336.39
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Product Details
CAS Number | 714272-27-2 | Appearance | |
Catalog Number | A852456 | MDL Number | MFCD18074510 |
Molecular Formula | C19H20N4O2 | Molecular Weight | 336.39 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | NPI2358;(3Z,6Z)-3-[(5-tert-Butyl-1H-imidazol-4-yl)methylene]-6-(phenylmethylene)-2,5-piperazinedione | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Plinabulin is a VDA of novel structure in having been derived from a marine microbial source, as opposed to terrestrial sources for other VDAs. Plinabulin binds to the colchicine binding site of b-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network. Plinabulin has been shown to produce anti-tumor activity in animal models as a single agent and synergistically with other chemotherapy agents including taxanes. Overall, preclinical studies indicated plinabulin had a favorable safety and activity profile leading to the initiation of clinical trials. Favorable data from early clinical studies lead to the initiation of a Phase 2 clinical trial program. |