Pracinostat
- Catalog NO.:A850037
- CAS No. : 929016-96-6
- Molecular Formula:C20H30N4O2
- Molecular Weight: 358.48
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Product Details
CAS Number | 929016-96-6 | Appearance | |
Catalog Number | A850037 | MDL Number | MFCD17215206 |
Molecular Formula | C20H30N4O2 | Molecular Weight | 358.48 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (2E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxyacrylamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Pracinostat, also known as SB939, is an orally bioavailable, small-molecule histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Pracinostat inhibits HDACs, which may result in the accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; the tumor suppressor protein-mediated inhibition of tumor cell division; and, finally, the induction of tumor cell apoptosis. In March 2014, pracinostat has granted Orphan Drug for acute myelocytic leukemia (AML) and for the treatment of T-cell lymphoma by the Food and Drug Administration. |