ARRY-380 Analog
- Catalog NO.:A859659
- CAS No. : 937265-83-3
- Molecular Formula:C29H27N7O4S
- Molecular Weight: 569.63
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Product Details
CAS Number | 937265-83-3 | Appearance | |
Catalog Number | A859659 | MDL Number | MFCD22420817 |
Molecular Formula | C29H27N7O4S | Molecular Weight | 569.63 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | ONT380 analog;6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H315-H319 | Class | |
Precautionary Statements | P305+P351+P338 | Packing Group |
Description
ARRY-380 analog is an analog of ARRY-380. ARRY-380 is also know as Tucatinib, also known as Irbinitinib, and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. |