HS-173
- Catalog NO.:A889169
- CAS No. : 1276110-06-5
- Molecular Formula:C21H18N4O4S
- Molecular Weight: 422.46
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Product Details
CAS Number | 1276110-06-5 | Appearance | Solid |
Catalog Number | A889169 | MDL Number | MFCD28023584 |
Molecular Formula | C21H18N4O4S | Molecular Weight | 422.46 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
HS-173 is a potent PI3Kα inhibitor with potential anticancer activity. HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G(2)/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1α and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro. Furthermore, HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. Therefore, HS-173 is considered as a novel drug candidate to treat cancer patients. |