WEHI-539 HCl
- Catalog NO.:A905324
- CAS No. : 2070018-33-4
- Molecular Formula:C31H30ClN5O3S2
- Molecular Weight: 620.18
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Product Details
CAS Number | 2070018-33-4 | Appearance | |
Catalog Number | A905324 | MDL Number | |
Molecular Formula | C31H30ClN5O3S2 | Molecular Weight | 620.18 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid hydrochloride | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | Class | ||
Precautionary Statements | Packing Group |
Description
WEHI-539 is a highly potent and selective BCL-XL inhibitor. The prosurvival BCL-2 family protein BCL-X(L) is often overexpressed in solid tumors and renders malignant tumor cells resistant to anticancer therapeutics. WEHI-539 has high affinity (subnanomolar) and selectivity for BCL-X(L) and potently kills cells by selectively antagonizing its prosurvival activity. WEHI-539 will be an invaluable tool for distinguishing the roles of BCL-X(L) from those of its prosurvival relatives, both in normal cells and notably in malignant tumor cells, many of which may prove to rely upon BCL-X(L) for their sustained. |