GDC-0941
- Catalog NO.:A11168
- CAS No. : 957054-30-7
- Molecular Formula:C23H27N7O3S2
- Molecular Weight: 513.64
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Product Details
CAS Number | 957054-30-7 | Appearance | Light yellow solid |
Catalog Number | A11168 | MDL Number | MFCD11616196 |
Molecular Formula | C23H27N7O3S2 | Molecular Weight | 513.64 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | Pictilisib;2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H332-H335 | Class | |
Precautionary Statements | P280-P305+P351+P338-P310 | Packing Group |
Description
Pictilisib, also known as Pictrelisib, GDC-0941, RG7321 and GNE0941 , is an orally bioavailable, and is a potent small-molecule thieno[3,2-d]pyrimidine inhibitor of the class I phosphatidylinositol 3 kinase (PI3K) isoforms p100alpha and p100delta with potential antineoplastic activity. PI3K inhibitor GDC-0941 selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway; inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations may result. |