LY2886721
- Catalog NO.:A889495
- CAS No. : 1262036-50-9
- Molecular Formula:C18H16F2N4O2S
- Molecular Weight: 390.41
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Product Details
CAS Number | 1262036-50-9 | Appearance | White powder |
Catalog Number | A889495 | MDL Number | MFCD22124078 |
Molecular Formula | C18H16F2N4O2S | Molecular Weight | 390.41 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | GHS07 | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
LY2886721 is a potent and selective BACE1 inhibitor. LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans. LY2886721 has high selectivity against key off-target proteases, which efficiently translates in vitro activity into robust in vivo amyloid β lowering in nonclinical animal models. Similar potent and persistent amyloid β lowering was observed in plasma and lumbar CSF when single and multiple doses of LY2886721 were administered to healthy human subjects. BACE1 is a key protease controlling the formation of amyloid β, a peptide hypothesized to play a significant role in the pathogenesis of Alzheimer's disease (AD). |