RO31-8220 mesylate
- Catalog NO.:A904072
- CAS No. : 138489-18-6
- Molecular Formula:C26H27N5O5S2
- Molecular Weight: 553.65
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Product Details
CAS Number | 138489-18-6 | Appearance | |
Catalog Number | A904072 | MDL Number | MFCD03788207 |
Molecular Formula | C26H27N5O5S2 | Molecular Weight | 553.65 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 3-(3-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl carbamimidothioate methanesulfonate;Ro 31-8220 mesylate | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%. Ro-31-8220 showed the apoptotic effect on HL-60 cells, which was mediated by a well-characterized transduction process of apoptotic signals: i.e., mitochondrial cytochrome c efflux and the activation of caspase-3 in the cytosol. Moreover, the ability of Ro-31-8220 to induce apoptotic activation was completely inhibited by the over-expression of the apoptotic suppressor gene, Bcl-2, in the cells. |