AM580
- Catalog NO.:A857382
- CAS No. : 102121-60-8
- Molecular Formula:C22H25NO3
- Molecular Weight: 351.44
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Product Details
CAS Number | 102121-60-8 | Appearance | |
Catalog Number | A857382 | MDL Number | MFCD00673916 |
Molecular Formula | C22H25NO3 | Molecular Weight | 351.44 |
Boiling Point | 461°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
AM-580 is a potent RARalpha agonist. AM580 has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. AM580 inhibited the wnt pathway, measured by loss of nuclear beta-catenin, suggesting partial oncogene dependence of therapy. Am580 treatment increased RARbeta and lowered the level of RARgamma, an isotype whose expression we linked with tumor proliferation. Specific activation of a single retinoic acid receptor-alpha (RARalpha), without direct and concurrent activation of RARbeta and gamma, will inhibit mammary tumor oncogenesis in murine models relevant to human cancer. |