Rolapitant
- Catalog NO.:A857744
- CAS No. : 552292-08-7
- Molecular Formula:C25H26F6N2O2
- Molecular Weight: 500.48
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Product Details
CAS Number | 552292-08-7 | Appearance | |
Catalog Number | A857744 | MDL Number | |
Molecular Formula | C25H26F6N2O2 | Molecular Weight | 500.48 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. |