BMS-833923
- Catalog NO.:A895916
- CAS No. : 1059734-66-5
- Molecular Formula:C30H27N5O
- Molecular Weight: 473.57
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Product Details
CAS Number | 1059734-66-5 | Appearance | Yellow powder |
Catalog Number | A895916 | MDL Number | MFCD25976660 |
Molecular Formula | C30H27N5O | Molecular Weight | 473.57 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | XL-139;N-(2-methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide. | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
BMS-833923, also known as XL-139, is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers. |