AT13148
- Catalog NO.:A895961
- CAS No. : 1056901-62-2
- Molecular Formula:C17H16ClN3O
- Molecular Weight: 313.78
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Product Details
CAS Number | 1056901-62-2 | Appearance | Off-white powder |
Catalog Number | A895961 | MDL Number | |
Molecular Formula | C17H16ClN3O | Molecular Weight | 313.78 |
Boiling Point | 595.9±50.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 is currently being developed by Astex Pharmaceuticals. AT131148 was identified utilizing high-throughput X-ray crystallography and fragment-based lead discovery techniques. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK and SGK substrate phosphorylation and induction of apoptosis in both a concentration and time-dependent manner in cancer cells with clinically relevant genetic defects both in vitro and in vivo. |