ON 01910 sodiuM salt
- Catalog NO.:A857758
- CAS No. : 1225497-78-8
- Molecular Formula:C21H24NNaO8S
- Molecular Weight: 473.47
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Product Details
CAS Number | 1225497-78-8 | Appearance | |
Catalog Number | A857758 | MDL Number | MFCD11655911 |
Molecular Formula | C21H24NNaO8S | Molecular Weight | 473.47 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-glycine,sodium salt (1:1);Rigosertib Sodium(Random Configuration) | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Rigosertib (ON-01910 sodium salt) is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo-like kinase 1 inhibitor ON 01910.Na inhibits polo-like kinase1 (Plk1), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. |