LY2603618
- Catalog NO.:A25224
- CAS No. : 911222-45-2
- Molecular Formula:C18H22BrN5O3
- Molecular Weight: 436.30
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 911222-45-2 | Appearance | Off-white powder |
Catalog Number | A25224 | MDL Number | MFCD00008740 |
Molecular Formula | C18H22BrN5O3 | Molecular Weight | 436.30 |
Boiling Point | 503.1±50.0°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | Rabusertib;IC-83;(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Rabusertib, also known as LY2603618, is a n inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types. |