GSK-923295
- Catalog NO.:A857635
- CAS No. : 1088965-37-0
- Molecular Formula:C32H38ClN5O4
- Molecular Weight: 592.13
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Product Details
CAS Number | 1088965-37-0 | Appearance | White to off-white powder |
Catalog Number | A857635 | MDL Number | MFCD16038931 |
Molecular Formula | C32H38ClN5O4 | Molecular Weight | 592.13 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
GSK-923295, also known as GSK-923295A, is a novel antimitotic inhibitor of centromere-associated protein E (CENP-E) with potential anticancer activity. GSK923295A demonstrated significant antitumor activity against solid tumor models, inducing CRs in Ewing sarcoma, rhabdoid, and rhabdomyosarcoma xenografts. Clinical study showed that GSK923295 had dose-proportional pharmacokinetics and a low number of grade 3 or 4 adverse events. The observed incidence of myelosuppression and neuropathy was low. Further investigations may provide a more complete understanding of the potential for GSK923295 as an antiproliferative agent. |