PAC-1
- Catalog NO.:A875881
- CAS No. : 315183-21-2
- Molecular Formula:C23H28N4O2
- Molecular Weight: 392.49
Note*
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 315183-21-2 | Appearance | White powder |
Catalog Number | A875881 | MDL Number | MFCD02051977 |
Molecular Formula | C23H28N4O2 | Molecular Weight | 392.49 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Danger | UN Number | 3077 |
Hazard Statements | H302-H315-H319-H335-H400 | Class | 9 |
Precautionary Statements | P261-P273-P305+P351+P338 | Packing Group | Ⅲ |
Description
PAC-1 is known as the first procaspase activating compound, which selectively induces apoptosis, or cell suicide, in cancerous cells. PAC-1 has shown good results in mouse models and is being further evaluated for use in humans. In 2010 a published study showed PAC-1 to be safe to research dogs, and a second study published later that same year reported that a PAC-1 derivative (called S-PAC-1) was well tolerated in a small Phase I Clinical Trial of pet dogs with lymphoma. Even at low doses of S-PAC-1, tumors regressed in 1/6 dogs, and the disease was stabilized (no additional tumor growth) in 3/6 dogs. |