Rolapitant hydrochloride hydrate
- Catalog NO.:A904660
- CAS No. : 914462-92-3
- Molecular Formula:C25H29ClF6N2O3
- Molecular Weight: 554.95
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Product Details
CAS Number | 914462-92-3 | Appearance | |
Catalog Number | A904660 | MDL Number | MFCD23105917 |
Molecular Formula | C25H29ClF6N2O3 | Molecular Weight | 554.95 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (5S,8S)-8-(((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one hydrochloride hydrate | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. |