PFI-1
- Catalog NO.:A851436
- CAS No. : 1403764-72-6
- Molecular Formula:C16H17N3O4S
- Molecular Weight: 347.39
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Product Details
CAS Number | 1403764-72-6 | Appearance | Beige solid |
Catalog Number | A851436 | MDL Number | MFCD22580416 |
Molecular Formula | C16H17N3O4S | Molecular Weight | 347.39 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
PFI-1 is a potent and highly selective protein interaction Inhibitor, which targets BET bromodomain. PFI-1 that efficiently blocks the interaction of BET BRDs with acetylated histone tails. Co-crystal structures showed that PFI-1 acts as an acetyl-lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD4 and BRD2. PFI-1 has antiproliferative effects on leukaemic cell lines and efficiently abrogates their clonogenic growth. Exposure of sensitive cell lines with PFI-1 results in G1 cell cycle arrest, down-regulation of MYC expression as well as induction of apoptosis and induces differentiation of primary leukaemic blasts. |