AT-9283 HCl
- Catalog NO.:A903965
- CAS No. : 896466-61-8
- Molecular Formula:C19H24ClN7O2
- Molecular Weight: 417.90
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Product Details
CAS Number | 896466-61-8 | Appearance | |
Catalog Number | A903965 | MDL Number | |
Molecular Formula | C19H24ClN7O2 | Molecular Weight | 417.90 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 1-cyclopropyl-3-(3-(6-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea hydrochloride | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | Class | ||
Precautionary Statements | Packing Group |
Description
AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a kinase that transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine kinase activity that is commonly found in CML. |