Mocetinostat HBr

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For R&D use only.

Catalog NO.：A904132
CAS No. : 944537-89-7
Molecular Formula：C₂₃H₂₁BrN₆O
Molecular Weight： 477.37

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Product Details

CAS Number	944537-89-7	Appearance
Catalog Number	A904132	MDL Number
Molecular Formula	C₂₃H₂₁BrN₆O	Molecular Weight	477.37
Boiling Point		Melting Point
Flash Point		Density
Synonyms	N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide HBr
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements		Class
Precautionary Statements		Packing Group

Description

Mocetinostat, also known as MGCD-0103, is a rationally designed, orally available, Class 1-selective, small molecule, 2-aminobenzamide HDAC inhibitor with potential antineoplastic activity. Mocetinostat binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others.

726169-73-9 (free base)

944537-89-7 (HBr)

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