LY294002
- Catalog NO.:A3395
- CAS No. : 154447-36-6
- Molecular Formula:C19H17NO3
- Molecular Weight: 307.12
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Product Details
CAS Number | 154447-36-6 | Appearance | White powder |
Catalog Number | A3395 | MDL Number | MFCD00270881 |
Molecular Formula | C19H17NO3 | Molecular Weight | 307.12 |
Boiling Point | 494.6°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 2-(4-Morpholinyl)-8-phenyl-4h-1-benzopyran-4-one | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H332-H335 | Class | |
Precautionary Statements | P261-P280-P305+P351+P338 | Packing Group |
Description
LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function. |