VRT752271 HCl
- Catalog NO.:A904735
- CAS No. : 1956366-10-1
- Molecular Formula:C21H23Cl3N4O2
- Molecular Weight: 469.79
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Product Details
CAS Number | 1956366-10-1 | Appearance | |
Catalog Number | A904735 | MDL Number | MFCD22543853 |
Molecular Formula | C21H23Cl3N4O2 | Molecular Weight | 469.79 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | Ulixertinib HCl;(S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide hydrochloride;Ulixertinib hydrochloride | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Ulixertinib, also known as BVD-523 and VRT752271, is an inhibitors of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. |