Obatoclax
- Catalog NO.：A904136
- CAS No. : 803712-67-6
- Molecular Formula：C20H19N3O
- Molecular Weight： 317.39
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Product Details
| CAS Number | 803712-67-6 | Appearance | |
| Catalog Number | A904136 | MDL Number | |
| Molecular Formula | C20H19N3O | Molecular Weight | 317.39 |
| Boiling Point | Melting Point | ||
| Flash Point | Density | ||
| Synonyms | GX 015070;2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole | ||
| Storage Condition | Store in a tightly closed container,in a cool and dry place | ||
Safety
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| Signal Word | Warning | UN Number | |
| Hazard Statements | Class | ||
| Precautionary Statements | Packing Group | ||
Description
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Obatoclax, also known as GX 015-070, a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl-2 protein family, preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells. The Bcl-2 family of proteins (bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers, including those of the lymphatic system, breast, lung, prostate, and colon. |
