GSK2837808A
- Catalog NO.:A941997
- CAS No. : 1445879-21-9
- Molecular Formula:C31H25F2N5O7S
- Molecular Weight: 649.62
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Product Details
CAS Number | 1445879-21-9 | Appearance | Light yellow powder |
Catalog Number | A941997 | MDL Number | MFCD28133406 |
Molecular Formula | C31H25F2N5O7S | Molecular Weight | 649.62 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 3-((3-(N-Cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(3,5-difluorophenoxy)benzoic acid | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | Packing Group |
Description
LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function. |