1,2,3,4,5,6-Benzenehexamine Trihydrochloride
- Catalog NO.:A929739
- CAS No. : 4444-26-2
- Molecular Formula:C6H15Cl3N6
- Molecular Weight: 277.58
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Product Details
CAS Number | 4444-26-2 | Appearance | Yellow brown powder |
Catalog Number | A929739 | MDL Number | |
Molecular Formula | C6H15Cl3N6 | Molecular Weight | 277.58 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 1,2,3,4,5,6-Benzenehexamine Trihydrochloride | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram |
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Signal Word | Warning | UN Number | |
Hazard Statements | H302;H315;H319;H335 | Class | |
Precautionary Statements | P261;P305+P351+P338 | Packing Group |
Description
LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function. |