Biotinyl Tyramide
- N ° de catalogue:A950579
- N ° CAS. : 41994-02-9
- Formule moléculaire:C18H25N3O3S
- Masse moléculaire: 363.47
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détails du produit
Numero CAS | 41994-02-9 | Apparence | |
Numéro de catalogue | A950579 | Numéro MDL | MFCD27953026 |
Formule moléculaire | C18H25N3O3S | Masse moléculaire | 363.47 |
Point d'ébullition | Point de fusion | ||
Point de rupture | Densité | ||
Synonymes | N-(4-Hydroxyphenethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | ||
Condition de stockage | Store in a tightly closed container,in a cool and dry place |
sécurité
Pictogramme SGH | |||
Mot de signal | Warning | Numéro UN | |
Mentions de danger | H302;H315;H319;H335 | Classe | |
Conseils de prudence | P261;P305+P351+P338 | Groupe d'emballage |
La description
Elacridar, also known as GF120918A, is a P-glycoprotein (P-gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects. |